PGD for dystrophin gene deletions using fluorescence in situ hybridization
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چکیده
منابع مشابه
PGD for dystrophin gene deletions using fluorescence in situ hybridization.
Duchenne muscular dystrophy and Becker muscular dystrophy (DMD and BMD) are caused by mutations in the dystrophin gene (Xp21). In two-thirds of DMD/BMD cases, the mutation is a large deletion of one or several exons. We have established PGD for DMD/BMD using interphase fluorescence in situ hybridization (FISH) analysis on single nuclei from blastomeres for the detection of deletions of specific...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2006
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gal039